Wamble grew up in Memphis and attended school at Memphis State, Northwestern University and the University of North Florida. During his time at UNF, he met future band members pianist Roy Dunlap, bassist Jeff Hanley and drummer Peter Miles. He has recorded with musicians such asWynton Marsalis on "Big Train" (1994) and "Unforgivable Blackness: The Rise and Fall of Jack Johnson" (2004), Cassandra Wilson on "Traveling Miles" (1999) and Branford Marsalis on "Romare Bearden Revealed" (2003). He has also toured with Madeleine Peyroux and Steven Bernstein’s Millennial Territory Orchestra. Wamble was signed to Marsalis Music/Rounder Records., a label started by saxophonist Branford Marsalis, in 2002. Country Libations was released in 2003, and Bluestate was released in 2005. In 2010, his self-titled album "Doug Wamble" was released on Koch/E1 records.
Most recently, Wamble's guitar playing was featured prominently in the Ken Burns' World War II documentary, The War on PBS. Wamble has also contributed music for the original scores for the upcoming Ken Burns documentary films, "The 10th Inning" and "Prohibition." Doug also completed the full original score for Burns' upcoming feature The Central Park Five, co-directed by Sarah Burns and produced by David McMahon of Florentine Films.
Doug's latest recording is entitled "Fast as Years, Slow as Days" and will be released in 2012.